[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"branding":3,"analytics":7,"article-scientists-coax-pancreatic-duct-cells-into-making-insulin":10,"sections":34},{"siteName":4,"siteTagline":5,"publisherName":4,"contactEmail":6},"The Revision","Tech news, decoded.","editor@therevision.news",{"gaMeasurementId":8,"adsenseClientId":9},"G-ZW2MV82GYR","ca-pub-8533917693782264",{"article":11},{"id":12,"slug":13,"title":14,"dek":15,"body_md":16,"tags_json":17,"published_at":18,"created_at":19,"updated_at":20,"status":21,"review_note":22,"review_notes":23,"image_url":22,"persona_id":22,"persona_name":22,"section":24,"tags":25,"sources":29,"feedback":33,"feedback_at":22,"cost_usd":33,"total_tokens":33},8000,"scientists-coax-pancreatic-duct-cells-into-making-insulin","Scientists Coax Pancreatic Duct Cells Into Making Insulin","Deactivating a single gene turned pancreatic duct cells into insulin producers, pointing toward a gene-therapy path for diabetes that skips transplants.","Turn off one gene, and a pancreatic duct cell can start acting like a beta cell.\n\nResearchers deactivated a single gene in cells lining the pancreatic ducts and turned them into insulin producers. Those duct cells don't normally make insulin, but once the gene was switched off, they began releasing it and helping regulate blood sugar. The finding suggests duct cells carry a kind of dormant backup plan for insulin production - one that a single genetic edit can unlock. The available report doesn't specify what stage this work is at, so how close it is to an actual treatment is still unclear.\n\nThat matters because most diabetes treatments work around insulin production instead of restoring it. People with type 1 diabetes typically inject insulin for life, and islet-cell transplants require lifelong immunosuppression to keep donor cells alive. If duct cells can be reprogrammed to do the job of destroyed beta cells, that points to a different strategy entirely: edit the cells patients already have instead of importing new ones.\n\nGene-editing news loves to promise a cure just around the corner. The actual corner here is still a lab bench - there's a long stretch between getting cells to produce insulin and treating diabetes in people.","[\"diabetes\",\"gene-therapy\",\"biotech\"]","2026-09-27T09:00:00.000Z","2026-09-27T10:18:55.150Z","2026-09-27T10:19:01.845Z","published",null,[],"science",[26,27,28],"diabetes","gene-therapy","biotech",[30],{"name":31,"url":32},"Wired","https:\u002F\u002Fwww.wired.com\u002Fstory\u002Fpancreatic-cells-just-one-genetic-tweak-away-from-treating-diabetes\u002F",0,{"sections":35},[36,41,46,51,56,61,64,69,74,79,84,89,93,98],{"name":37,"slug":38,"count":39,"latest_published_at":40},"AI","ai",4639,"2026-09-27T12:47:50.000Z",{"name":42,"slug":43,"count":44,"latest_published_at":45},"Security","security",753,"2026-09-27T14:14:40.000Z",{"name":47,"slug":48,"count":49,"latest_published_at":50},"Policy","policy",397,"2026-09-27T13:57:03.000Z",{"name":52,"slug":53,"count":54,"latest_published_at":55},"Deals","deals",260,"2026-09-26T09:00:00.000Z",{"name":57,"slug":58,"count":59,"latest_published_at":60},"Hardware","hardware",186,"2026-09-26T17:26:54.000Z",{"name":62,"slug":24,"count":63,"latest_published_at":18},"Science",145,{"name":65,"slug":66,"count":67,"latest_published_at":68},"Consumer Tech","consumer-tech",135,"2026-09-26T14:30:00.000Z",{"name":70,"slug":71,"count":72,"latest_published_at":73},"Software","software",91,"2026-09-25T20:55:00.000Z",{"name":75,"slug":76,"count":77,"latest_published_at":78},"Dev Tools","dev-tools",84,"2026-09-26T04:20:58.000Z",{"name":80,"slug":81,"count":82,"latest_published_at":83},"Startups","startups",76,"2026-09-25T18:33:59.000Z",{"name":85,"slug":86,"count":87,"latest_published_at":88},"Gaming","gaming",48,"2026-09-25T18:35:21.000Z",{"name":90,"slug":91,"count":87,"latest_published_at":92},"General","general","2026-09-26T17:02:42.000Z",{"name":94,"slug":95,"count":96,"latest_published_at":97},"Reviews","reviews",30,"2026-09-24T20:07:31.000Z",{"name":99,"slug":100,"count":101,"latest_published_at":102},"How-To","how-to",6,"2026-06-16T09:00:00.000Z"]