[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"branding":3,"analytics":7,"article-ai-protein-design-tool-builds-sequence-and-structure-together":10,"sections":35},{"siteName":4,"siteTagline":5,"publisherName":4,"contactEmail":6},"The Revision","Tech news, decoded.","editor@therevision.news",{"gaMeasurementId":8,"adsenseClientId":9},"G-ZW2MV82GYR","ca-pub-8533917693782264",{"article":11},{"id":12,"slug":13,"title":14,"dek":15,"body_md":16,"tags_json":17,"published_at":18,"created_at":19,"updated_at":20,"status":21,"review_note":22,"review_notes":23,"image_url":22,"persona_id":22,"persona_name":22,"section":24,"tags":25,"sources":30,"feedback":34,"feedback_at":22,"cost_usd":34,"total_tokens":34},9757,"ai-protein-design-tool-builds-sequence-and-structure-together","AI Protein Design Tool Builds Sequence and Structure Together","CODesign, a new open-source model, generates protein sequence and structure together for state-of-the-art binder design results in simulation.","A new AI model designs protein binders by generating their sequence and three-dimensional shape at the same time, rather than one after the other.\n\nThe model, called CODesign, tackles a basic mismatch problem in protein design: a sequence has to fold into the structure you wanted, and the structure has to accommodate that exact sequence. Most existing tools handle this in two separate steps, first generating a backbone shape, then designing a sequence to fit it, which leaves room for the two to drift out of sync. CODesign instead uses a single multimodal model that jointly captures sequences, backbone structures, and the fine atomic detail of side chains, then iteratively refines both through a consistency-aware resampling step. To train it, the researchers also built a new dataset of roughly 105,000 consistency-distilled protein dimers, which the paper's own ablation tests credit with a 70.9% performance gain by itself.\n\nThe payoff, per the paper, is state-of-the-art in silico success rates for both protein-target and ligand-target binder design, the kind of task that matters for antibody and small-molecule drug development. That is the real pitch here: designing a binder that works usually means getting sequence and structure right at once, not bolting them together afterward, and two-stage pipelines have stuck around precisely because joint generation is hard to do without the parts fighting each other.\n\nAll the usual caveats for in silico results apply. These are computational success metrics, not lab-confirmed binders, so the real test comes when someone actually expresses and assays the proteins CODesign produces. The code, weights, and dataset are slated for open release, which at least means outside labs can run that test themselves.","[\"protein-design\",\"generative-ai\",\"open-source\",\"drug-discovery\"]","2026-10-02T04:00:00.000Z","2026-10-03T09:15:15.467Z","2026-10-03T09:15:20.943Z","published",null,[],"science",[26,27,28,29],"protein-design","generative-ai","open-source","drug-discovery",[31],{"name":32,"url":33},"arXiv cs.AI","https:\u002F\u002Farxiv.org\u002Fabs\u002F2610.01773",0,{"sections":36},[37,41,45,49,54,58,61,66,71,76,81,86,91,96],{"name":38,"slug":39,"count":40,"latest_published_at":18},"AI","ai",6041,{"name":42,"slug":43,"count":44,"latest_published_at":18},"Security","security",848,{"name":46,"slug":47,"count":48,"latest_published_at":18},"Policy","policy",439,{"name":50,"slug":51,"count":52,"latest_published_at":53},"Deals","deals",317,"2026-10-01T22:00:00.000Z",{"name":55,"slug":56,"count":57,"latest_published_at":18},"Hardware","hardware",199,{"name":59,"slug":24,"count":60,"latest_published_at":18},"Science",176,{"name":62,"slug":63,"count":64,"latest_published_at":65},"Consumer Tech","consumer-tech",155,"2026-10-01T19:54:10.000Z",{"name":67,"slug":68,"count":69,"latest_published_at":70},"Dev Tools","dev-tools",96,"2026-10-01T16:57:03.000Z",{"name":72,"slug":73,"count":74,"latest_published_at":75},"Software","software",93,"2026-09-30T21:41:11.000Z",{"name":77,"slug":78,"count":79,"latest_published_at":80},"Startups","startups",90,"2026-10-01T21:55:22.000Z",{"name":82,"slug":83,"count":84,"latest_published_at":85},"Gaming","gaming",53,"2026-10-02T02:50:39.000Z",{"name":87,"slug":88,"count":89,"latest_published_at":90},"General","general",50,"2026-09-30T21:37:54.000Z",{"name":92,"slug":93,"count":94,"latest_published_at":95},"Reviews","reviews",31,"2026-09-28T14:31:34.000Z",{"name":97,"slug":98,"count":99,"latest_published_at":100},"How-To","how-to",7,"2026-10-01T09:00:00.000Z"]